Price: $7.55
(as of Oct 24, 2025 15:12:23 UTC – Details)
Use Desitin Daily Defense Diaper Rash Cream every day to soothe, treat and prevent diaper rash. This hypoallergenic and Pediatrician-tested formula instantly forms a protective barrier on your baby’s tender skin and is clinically shown to provide diaper rash relief. It is designed to work at the first hint of diaper rash to help heal and soothe your baby’s skin. Made with fast-acting zinc oxide formula, this diaper cream helps seal out wetness and provides protection from the first use. It is dermatologist-tested and free of parabens, phthalates, and dyes, so it’s gentle enough to use at every diaper change. The creamy formula goes on smoothly and wipes off easily, making Desitin Daily Defense Diaper Rash Cream your trusted partner for treating diaper rash from the first signs.
Is Discontinued By Manufacturer : No
Product Dimensions : 1.77 x 2.43 x 7.1 inches; 4.8 ounces
Item model number : 693
Date First Available : September 9, 2014
Manufacturer : Kenvue
ASIN : B07H7GBJC4
Best Sellers Rank: #976 in Baby (See Top 100 in Baby) #27 in Diaper Creams
Customer Reviews: 4.8 4.8 out of 5 stars 6,700 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
4.8-ounce tube of Desitin Daily Defense Diaper Rash Cream works from the first use to help soothe, treat and prevent diaper rash
From the #1 choice for diaper rash relief by Pediatricians and parents, this infant diaper cream instantly forms a protective layer on your baby’s skin for diaper rash relief and prevention
Made with zinc oxide, its fast-acting hypoallergenic formula helps seal out wetness to treat diaper rash from the first signs and is clinically shown to provide diaper rash relief
This diaper cream is specially formulated for babies’ tender skin and is paraben-, phthalate- and dye-free so it’s gentle enough to use at every diaper change
Its creamy formula goes on smoothly and wipes off easily, making Desitin Daily Defense Diaper Rash Cream your trusted partner for treating diaper rash from the first signs
13 reviews for Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide to Treat, Relieve & Prevent diaper rash, Hypoallergenic, Dye-, Phthalate- & Paraben-Free, 4.8 oz
Add a review
$7.55









bookreader –
Amazing
Works fantastic. Very oily and hard to get off your hands. I actually use a glove. But you can’t beat it for protection and clearing up diaper area rash. Little bit goes a long way. This tube will last years.
Nakki Xo –
Great Product!⭐️⭐️
This cream is a lifesaver! It’s gentle, goes on smoothly without being greasy, and really helps protect my baby’s skin. I noticed redness gone within hours, and it’s great for preventing rashes before they start. Plus the subtle scent is a bonus!
Boiler1maker –
The always trusted… DESITIN! Does what it always has, clears redness and rash.
It’s Desitin. Does a fine job for adults and children alike. Soothes unwanted rash easily.
J. E. –
Proven excellent product, used by consumers for years.
Product has been around for years, this brand is excellent. Buttered all my babies butts with this, use it now myself for skin irritations.
hannah –
baby must have!!
we absolutely love this product!! we use it almost daily for our son when he needs it and it works so well and fast!!
Harry garner –
Great diaper rash cream
We’ve been using desitin since my baby was a newborn for diaper rash and it works great! It heals diaper rash easily.
Customer –
Recommended by the derm. Safe ingredients and effective
The derm recommended this variety of Design. It works well and doesn’t contain anything that might irritate sensitive skin. Very effective.
Mari leidy Perez –
Baby care
I realmente like its effects, although i would prefer it to be softer to the touch.
FS –
It’s smoothing the skin so the rash doesn’t get worse
Kunjumary Dominic –
You should check your expiry before you buy the item. The tube is quite big and you can use it for 2 years actually. The amazon is selling all the old items which expires soon to the customers and item is non refundable also. The product is quite expensive also. I have bought the another tube in 2021 and which expires in December 2023. This year January 2024 I ordered another one which expires on 7/2024 which I can hardly use it only for 6 months. Please don’t buy these products from Amazon. The product is really good but not from Amazon.
Sara Habjoka –
Very happy with this, removed diaper rash so quickly
AmazonCustomer –
Effective cream. Bought them on sale. So great value!
Joseph –
Why is it so watery now? Earlier it was a thicker consistency.